이영주 교수
Young-Ju Lee
한양대학교 신경과 · 의학
연구실 소개
이영주 교수의 연구실은 간질환의 진단 및 치료 전략 개발에 초점을 맞추고 있으며, 특히 간 이식에서의 혈관 해부학적 이상 대응 및 간 기능 평가 기술 개선을 핵심 연구 분야로 삼고 있습니다. 유전자 발현 조절 및 약물 내성 메커니즘을 규명하기 위한 분자생물학적 연구와 함께, MRI 및 PET/CT를 활용한 간질환의 정밀 진단 기술 개발도 진행 중입니다. 특히, 간 지방질성 간염의 정확한 생체 영상 측정법과 암 치료에서의 약물 저항성 극복 전략에 대한 응용 연구가 두드러집니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Preservation and reconstruction of the MHV tributaries is recommended to prevent congestion of the right liver graft without MHV.
OBJECTIVE: Tamoxifen is currently used for the treatment of estrogen receptor-positive breast cancer patients, but acquired resistance to tamoxifen is a critical problem in breast cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is a prototype of the newly developed HDAC inhibitor. The aim of this study is to investigate the anticancer effects of SAHA in tamoxifen-resistant MCF-7 (TAMR/MCF-7) cells. METHODS: Cytotoxicity, apoptosis and autophagic cell death induced by SAHA were studied. A
The multiecho and multi-interference MRI methods and MRS can accurately quantify hepatic fat, with coexisting histologic abnormalities having no confounding effects.
PURPOSE: We investigated the prognostic effect of incorporating metabolic assessment by (18)F-fluoro-2-deoxyglucose uptake on positron emission tomography/computed tomography ((18)F-FDG-PET/CT) into a conventional staging system in small-cell lung cancer (SCLC). EXPERIMENTAL DESIGN: Seventy-six consecutive patients with pathologically proven SCLC were enrolled. All patients underwent standard treatment after pretreatment (18)F-FDG-PET/CT scanning. The mean values of maximal standardized uptake v
Right lobe living-donor liver transplantation (LDLT) is often not attempted in donors with anomalous portal venous branching (APVB). The authors describe their experience with portal vein (PV) reconstruction in 17 cases of APVB in right lobe LDLT. From July 1997 to December 2001, 214 right liver LDLT were performed at the Asan Medical Center. Seventeen of the donors had APVB and successfully underwent right lobectomy. The APVB were type II (trifurcation) in nine cases, type III (independent post
In this paper, we discuss convergence results for general (successive) subspace correction methods for solving nearly singular systems of equations. We provide parameter independent estimates under appropriate assumptions on the subspace solvers and space decompositions. The main assumption is that any component in the kernel of the singular part of the system can be decomposed into a sum of local (in each subspace) kernel components. This assumption also covers the case of "hidden" nearly singu
OBJECTIVES: Glucose homeostasis changes after pancreatic resection are not well understood. We aimed to identify the incidence of, and risk factors for, a change in glucose homeostasis in patients who underwent pancreatectomy for benign pancreatic tumors. METHODS: Clinical and pathological data from 229 patients were collected prospectively and analyzed retrospectively. The pancreas resection volume was calculated by computed tomography volumetry. RESULTS: After pancreatectomy, newly diagnosed d
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