윤영남 교수

BACKGROUND: Cardiopulmonary bypass may exacerbate myocardial damage in compromised left ventricles. Early and mid-term outcomes of off-pump coronary artery bypass grafting (OPCAB) vs on-pump coronary artery bypass grafting (On-pump CABG) were compared in patients with poor left ventricular dysfunction, using an analysis of a propensity score matching. METHODS AND RESULTS: Between December 2000 and November 2005, 1,473 patients underwent isolated coronary artery bypass grafting in our institute a

Artificial vessels capable of long-term patency are essential clinical tools in vascular surgery that involves small vessels. On-going attempts to develop artificial vessels that complements restenosis have not been entirely successful. Here, we report on the fabrication of small-sized artificial vessels using a three-dimensional bio-printer. The fabrication employed biodegradable polycaprolactone and autologous MSCs harvested from the bone-marrow of canines. The MSCs were cultured and different

OBJECTIVE: To determine whether plasma cystatin C and creatinine levels after isolated off-pump coronary artery bypass grafting (OPCAB) are predictive of postoperative renal dysfunction and clinical outcomes. METHODS: Between January 2008 and December 2013, 1033 who underwent isolated OPCAB were recruited. The patients were divided into three groups according to the preoperative level of cystatin C: low (0.83 mg/L>), mid (0.83-1.13 mg/L) and high (1.13 mg/L<). The endpoints of all-cause mortalit

충남 아산의 보리와 헤어리베치가 혼작된 포장과 대전 유성의 헤어리베치 포장에서 5월 중순부터 채종 후인 7월 중순까지 집합페로몬트랩을 이용해 유인된 톱다리개미허리노린재의 발생양상을 조사한 결과, 종자의 결실이 이루어지는 6월 하순부터 포장내로 유입되어 들어오는 개체수가 증가하기 시작하였으나 7월 중순 채종작업이 끝나면서 유입개체가 감소하는 경향을 보였으며, 이후에도 11월 초까지 계속적으로 유인되는 것이 확인되었다. 헤어리베치 포장에서는 톱다리개미허리노린재 외에도 닮은수염노린재, 알락수염노린재, 변색장님노린재, 실노린재를 포함한 총 33종의 노린재목 곤충이 채집되어 많은 종류의 노린재류들이 서식하고 있음을 알 수 있었다. 실내에서는 헤어리베치를 먹이로 제공하였을 경우에는 정상적인 발육이 이루어지지 않았으며, 4령 약충 이후부터 생존율이 감소하고 성충으로의 우화가 이루어지지 않았으며, 먹이 선호성에 있어서도 헤어리베치보다는 콩을 더 선호하는 것으로 나타났다. 결과적으로 헤어리베치는 톱

Replacement of small-sized vessels is still challenging. This study is aimed at investigating the possibility of small-sized artificial vessels made by 3-dimensional bioprinting and the effect of pulsatile flow on bMSC-derived endothelial-like cells. Cells were harvested from rabbit bone marrow and primary cultured with or without growth factors. Endothelial differentiation was confirmed by the Matrigel tube formation assay, Western blot, and qRT-PCR. In addition, embedment of endothelial-like c

Restenosis at a vascular anastomosis site is a major cause of graft failure and is difficult to prevent by conventional treatment. Perivascular drug delivery has advantages as drugs can be diffused to tunica media and subintima while minimizing the direct effect on endothelium. This in vivo study investigated the comparative effectiveness of paclitaxel, sirolimus, and sunitinib using a perivascular biodegradable microneedle cuff. A total of 31 New Zealand white rabbits were used. Rhodamine was u

BACKGROUND: Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions. We aimed to assess the efficacy of high-dose rosuvastatin loading in patients with stable angina undergoing off-pump coronary artery bypass grafting (OPCAB). MATERIALS AND METHODS: A total of 142 patients with stable angina who were scheduled to undergo surgical myocardial revascularization were randomized to receive either

Hybrid arch repair conferred a significantly lower incidence of pulmonary complications, without benefitting perioperative mortality and stroke. However, open repair proved more reliable, showing greater durability. Long-term investigations are needed to confirm the viability and safety of hybrid repair as an alternative treatment in this setting.