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김영서 교수

Young Seo Kim

한양대학교 신경과 · 의학

연구실 소개

김영서 교수의 연구실은 주로 생체분자의 생리적 기능과 병리적 변화를 밝혀내는 데 초점을 맞추고 있으며, 특히 당뇨, 뇌졸중, 암 등 만성질환과 관련된 생화학적 메커니즘을 탐구하고 있습니다. 고분자 생물학과 생물물리화학적 기법을 접목해 단백질, 점액질, 효소의 기능적 특성과 관련된 기전을 규명하고 있으며, 특히 스타링, 점액질 MUC3/MUC4, MMP-9 등의 분자적 역할에 대한 연구가 두드러집니다. 이와 더불어, 뇌졸중 환자의 조기 진료 지연 원인 분석 및 국민 대상의 뇌졸중 인식도 평가를 통해 임상적 응용가능성을 확장하고 있습니다.

뇌졸중점액질MMP-9생화학적 기전임상 연구

연구 현황

논문 수
237
총 인용 수
3,762
최근 5년 논문
78
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
78총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
250총합
20222023202420252026

주요 논문

15
1
논문|인용수 198·1995
Screening Potato Starch for Novel Properties Using Differential Scanning Calorimetry
Young Seo Kim, Dennis P. Wiesenborn, P. H. Orr, L. A. Grant
SJR Q1Journal of Food Science

ABSTRACT T hermal and other physicochemical properties of starch from 42 potato genotypes were studied to find those with unique properties for food use, and to analyze relationships between thermal and other physicochemical properties. Onset and peak transition temperatures and gelatinization enthalpy intercorrelated. Transition temperatures intercorrelated with pasting temperature using a Brabender Visco‐amylograph. Gelatinization entbalpy correlated with Brabender pasting temperature and peak

Nutrition and DieteticsNursing
2
논문|인용수 137·2011
Stroke awareness decreases prehospital delay after acute ischemic stroke in korea
Young Seo Kim, Sang‐Soon Park, Hee‐Joon Bae, A-Hyun Cho, Yong‐Jin Cho, Moon‐Ku Han, Ji Hoe Heo, Kyusik Kang, Dong‐Eog Kim, Hahn Young Kim, Gyeong‐Moon Kim, Sun Uk Kwon
SJR Q2BMC NeurologyOA

BACKGROUND: Delayed arrival at hospital is one of the major obstacles in enhancing the rate of thrombolysis therapy in patients with acute ischemic stroke. Our study aimed to investigate factors associated with prehospital delay after acute ischemic stroke in Korea. METHODS: A prospective, multicenter study was conducted at 14 tertiary hospitals in Korea from March 2009 to July 2009. We interviewed 500 consecutive patients with acute ischemic stroke who arrived within 48 hours. Univariate and mu

EpidemiologyMedicine
3
논문|인용수 103·2003
Aberrant Expression of MUC3 and MUC4 Membrane-Associated Mucins and Sialyl Lex Antigen in Pancreatic Intraepithelial Neoplasia
Hee–Ug Park, Jong‐Woo Kim, Grace Kim, Han‐Ik Bae, Suzanne Crawley, Stacey C. Yang, James R. Gum, Surinder K. Batra, Karine Rousseau, Dallas M. Swallow, Marvin H. Sleisenger, Young Seo Kim
SJR Q2Pancreas

Aberrant expression of membrane mucins MUC3 and MUC4 and of a mucin-associated carbohydrate tumor antigen Sialyl Le(x) in PanINs and adenocarcinoma further supports the progression model for pancreatic adenocarcinoma.

OncologyMedicine
4
논문|인용수 101·1972
Glycosyltransferases in human blood
Young Seo Kim, Jose Perdomo, James S. Whitehead
SJR Q1Journal of Clinical InvestigationOA

Human serum and hemoglobin-free erythrocyte membranes were found to contain a galactosyltransferase which catalyzes the transfer of galactose from UDP-galactose to specific large and small molecular weight acceptors. The requirements for enzyme activity were found to be similar for the enzymes from both sources. However, the membrane-bound enzyme depended on a detergent for maximal activity. Mn(++) was an absolute requirement for transfer and uridine nucleoside phosphates were inhibitors. The mo

SurgeryMedicine
5
논문|인용수 60·2012
The advantage of high-resolution MRI in evaluating basilar plaques: A comparison study with MRA
Young Seo Kim, Sunghwan Lim, Ki‐Wook Oh, Ji Young Kim, Seong‐Ho Koh, Juhan Kim, Sung Hyuk Heo, Dae‐Il Chang, Young‐Jun Lee, Hyun Young Kim
SJR Q1Atherosclerosis
Pulmonary and Respiratory MedicineMedicine
6
논문|인용수 57·2011
Public Awareness of Stroke in Korea
Young Seo Kim, Sang-Soon Park, Hee‐Joon Bae, Ji Hoe Heo, Sun U. Kwon, Byung‐Chul Lee, Seung‐Hoon Lee, Chang Wan Oh, Byung‐Woo Yoon
SJR Q1StrokeOA

BACKGROUND AND PURPOSE: To date, no large study has been conducted to investigate baseline stroke awareness within a nationally representative sample of the Korean population. METHODS: A total of 1000 residents were randomly sampled according to regional demographic characteristics and were interviewed in person by trained interviewers. Structured, open-ended and close-ended questions were asked to assess stroke awareness. RESULTS: Among the respondents, 62% reported at least 1 stroke symptom an

EpidemiologyMedicine
7
논문|인용수 50·2018
Regulatory T cells increase after treatment with poly (ADP-ribose) polymerase-1 inhibitor in ischemic stroke patients
Min‐Young Noh, Won Moo Lee, Su Jung Lee, Hyun Young Kim, Seung Hyun Kim, Young Seo Kim
SJR Q1International Immunopharmacology
NeurologyNeuroscience
8
논문|인용수 48·2014
Hypoxia/Reoxygenation-Preconditioned Human Bone Marrow-Derived Mesenchymal Stromal Cells Rescue Ischemic Rat Cortical Neurons by Enhancing Trophic Factor Release
Young Seo Kim, Min‐Young Noh, Kyung‐Ah Cho, Hyemi Kim, Min‐Soo Kwon, Kyung Suk Kim, Juhan Kim, Seong‐Ho Koh, Seung Hyun Kim
SJR Q1Molecular Neurobiology
GeneticsMedicine
9
논문|인용수 42·1978
Determination of free Ca ion concentrations with an ion-selective electrode in the presence of chelating agents in comparison with calculated values
Young Seo Kim, George M. Padilla
SJR Q3Analytical Biochemistry
BioengineeringChemical Engineering
10
논문|인용수 41·2006
The Role of Matrix Metalloproteinase 9 in Early Neurological Worsening of Acute Lacunar Infarction
Young Seo Kim, Kyu‐Yong Lee, Seong‐Ho Koh, Chang Yun Park, Ho Kim, Young Joo Lee, Hee-Tae Kim, Juhan Kim, Myung‐Ho Kim, Kyung Suk Kim, Dae‐Il Chang, Seung Hyun Kim
SJR Q3European Neurology

The involvement of matrix metalloproteinases (MMPs) in ischemic-stroke-induced inflammatory response has recently been suggested; however, the relationship between MMPs and stroke progression has not been evaluated. We investigated the role of MMPs in neurological worsening of acute lacunar infarction. Forty-nine consecutive patients with an acute lacunar infarction (as defined by clinical and MRI criteria within 48 h after stroke onset) were evaluated. Clinical, biochemical, rheological, inflam

Cancer ResearchBiochemistry, Genetics and Molecular Biology
11
논문|인용수 38·2013
Direct GSK-3β Inhibition Enhances Mesenchymal Stromal Cell Migration by Increasing Expression of Beta-PIX and CXCR4
Young Seo Kim, Min‐Young Noh, Ji Young Kim, Hyun‐Jeung Yu, Kyung Suk Kim, Seung Hyun Kim, Seong‐Ho Koh
SJR Q1Molecular Neurobiology
GeneticsMedicine
12
논문|인용수 33·2017
Range of glucose as a glycemic variability and 3–month outcome in diabetic patients with acute ischemic stroke
Young Seo Kim, Chulho Kim, Keun‐Hwa Jung, Hyung‐Min Kwon, Sung Hyuk Heo, Beom Joon Kim, Young Dae Kim, Jeong‐Min Kim, Seung‐Hoon Lee
SJR Q1PLoS ONEOA

Glycemic variability (GV) is reportedly a predictor for poor outcome in various clinical conditions. We aimed to assess whether GV during hospital admission is associated with poor outcomes in patients with acute ischemic stroke (AIS) and diabetes. We prospectively enrolled consecutive patients with AIS from the registry of 6 tertiary hospitals between January 2013 and December 2014. For the GV index, we used a glucose level range that was divided into 4 quartiles. Multivariable binary and ordin

EpidemiologyMedicine
13
논문|인용수 29·1974
Effects of salinity on synthesis of DNA, acidic polysaccharide, and ichthyotoxin in Gymnodinium breve
Young Seo Kim, Dean F. Martin
SJR Q1Phytochemistry
Environmental ChemistryEnvironmental Science
14
논문|인용수 28·2019
Distal versus Proximal Middle Cerebral Artery Occlusion: Different Mechanisms
Young Seo Kim, Bum Joon Kim, Kyung Chul Noh, Kyung Mi Lee, Sung Hyuk Heo, Hye‐Yeon Choi, Hyun Young Kim, Seong‐Ho Koh, Dae‐Il Chang
SJR Q2Cerebrovascular Diseases

BACKGROUND: Clinical and radiological characteristics of middle cerebral artery (MCA) infarction may differ according to the location of occlusion. OBJECTIVES: We investigated the difference between proximal and distal symptomatic MCA occlusion (MCAO) in patients with ischemic stroke. The factors associated with the imaging characteristics were also analyzed. METHODS: Patients with ischemic stroke due to MCAO were consecutively enrolled. The location of MCAO was determined by the ratio of the le

EpidemiologyMedicine
15
논문|인용수 24·2016
Early Activation of Phosphatidylinositol 3-Kinase after Ischemic Stroke Reduces Infarct Volume and Improves Long-Term Behavior
Young Seo Kim, Arum Yoo, Jeong Woo Son, Hyun Young Kim, Young‐Jun Lee, Se Jin Hwang, Kyu‐Yong Lee, Young Joo Lee, Cenk Ayata, Hyung-Hwan Kim, Seong‐Ho Koh
SJR Q1Molecular Neurobiology
Geriatrics and GerontologyMedicine

대표 연구 분야

OncologyNeurologyEpidemiologyRheumatologyPulmonary and Respiratory MedicineAtomic and Molecular Physics, and Optics

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