최영식 교수

The anharmonic mixing of highly excited vibrational states of HFCO above its dissociation threshold is studied by stimulated emission pumping spectroscopy. At 0.05-cm−1 resolution, individual molecular eigenstates were resolved and state mixings observed by the distribution of oscillator strength to nearby dark states of the background. Most of the zero-order vibrational levels observed in the energy range between 13 000 and 23 000 cm−1 are assigned to long Franck–Condon-allowed progressions of

Rovibrationally resolved unimolecular reaction rates of highly vibrationally excited HFCO (S0) are measured and found to be strongly state specific in the energy range of 14 500 cm−1–23 000 cm−1. HFCO molecules are excited to single rovibrational levels in the tunneling region by stimulated emission pumping (SEP) and the dissociation rate of each level is measured by monitoring the temporal evolution of its population by laser-induced fluorescence. The dissociation rates increase by a factor of

The aim of this study was to compare intrafollicular biomarkers of thiol-redox system and chronic inflammation in infertile patients with and without endometriosis, and examine correlations between biomarkers and IVF outcomes. The study included 65 patients receiving IVF: 31 patients with endometriosis vs 34 patients without endometriosis. Follicular fluid (FF) was obtained from a single-dominant follicle during oocyte retrieval and stored at -70 °C. Malondialdehyde, superoxide dismutase, glutat

Stimulated emission pumping spectra of HFCO in a pulsed jet at 0.2 cm−1 resolution in the range of 13 000 to 23 000 cm−1 are reported. Above the dissociation threshold, ≊14 000 cm−1, linewidths vary from 0.15 to 2.0 cm−1 for S0 vibrational levels within an energy range of a few hundreds of cm−1 . Substantial vibrational mode dependence of intramolecular vibrational energy redistribution and/or dissociation rates is likely.

Rovibrational state distributions and Doppler widths of CO fragments formed from unimolecular dissociation of HFCO in its ground electronic state are measured by vacuum ultraviolet laser-induced fluorescence, following state-selective preparation of the molecule in a single quantum state in the energy region of 2000 to 3000 cm−1 above the dissociation threshold by stimulated emission pumping. CO fragments are rotationally hot and distributed over J≤15 to J=63 with distributions peaking at J=45 t

The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly

Women with old age, longer duration of infertility, the presence of endometriosis or thin endometrium in the preovulatory phase may have unfavorable outcomes during the first four IUI cycles.

BACKGROUND: Insulin-like growth factors (IGF) and their binding proteins (IGFBP) play a major role in the autocrine and paracrine regulation of folliculogenesis. This is the first study that has compared follicular fluid (FF) IGF-I, IGF-II, IGFBP-3, IGFBP-4 and pregnancy-associated plasma protein (PAPP)-A concentrations, and their ratios, to investigate whether there was any difference in the intrafollicular microenvironment between the GnRH agonist (GnRHa) and antagonist (GnRHant) protocols for

<b>Background:</b> Repair of DNA double strand break (DSB) is an important mechanism for maintaining genetic stability during a DNA damage event. Although, a growing body of recent evidence suggests that DNA DSBs and related repair mechanisms may be important in ovarian aging and in various cancers, there are few reports in endometriosis. We, therefore, examined expression levels of genes pertaining to DNA DSB repair in patients with endometriosis to assess the potential effects on ovarian reser

The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in the treatment of dysmenorrhea associated with adenomyosis. However, the mechanism of pain relief of LNG-IUS in patients with adenomyosis is unclear. We aimed to investigate the effects of LNG-IUS on the expression of nerve growth factor (NGF) and its receptors, NGFR p75 and TrkA in patients with adenomyosis. Endometrial and myometrial tissues were prepared from 17 LNG-IUS-treated patients and 15 hormonally untreated patie

PROBLEM: Recently, interleukin (IL)-32 has been suggested to be involved in the pathogenesis of endometriosis. The aim of this study was to investigate whether serum IL-32 level might be used as a biomarker for diagnosis of endometriosis. METHOD OF STUDY: We recruited the serum samples of 50 patients with histologically confirmed endometriosis and 35 controls. Enzyme-linked immunosorbent assay was used to analyze the serum IL-32, IL-6, IL-10, tumour necrosis factor (TNF)-α, IL-1β, and CA-125 lev

Stimulated-emission pumping is successfully applied to the study of unimolecular dissociation dynamics of HFCO → HF + CO in a pulsed jet. Dissociative levels of the ground electronic state are prepared by stimulated-emission pumping, and the CO fragments formed from these levels are probed by vacuum-ultraviolet laser-induced fluorescence spectroscopy. The rotational energy distribution of the CO fragments indicates modest differences between the dissociation dynamics of HFCO and those of H2CO. H

Aquaporins (AQPs) are involved in cell migration, proliferation and carcinogenesis in tumor development and physiologic inflammatory processes, but their associations with endometriosis have not been fully evaluated. In this study, tissue samples were obtained from women undergoing laparoscopic surgery for endometriosis and other benign conditions. Analysis of expressions of AQP subtypes in eutopic and ectopic endometrium of patients with endometriosis (Eu-EMS and Ect-EMS, respectively) and euto