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이영희 교수

Younghee Lee

서울대학교 수의학과 · 보건학

연구실 소개

이영희 교수의 연구실은 식이 행동의 신경기반 조절 메커니즘을 밝히는 데 초점을 맞추고 있습니다. 특히 뇌의 측부하악체(LH) 내 레프틴 수용체를 지닌 신경세포가 식욕 유도와 식사 행동의 두 단계인 탐색 행동과 섭취 행동을 어떻게 조절하는지에 대해 광섬유 광측정 및 마이크로엔도스코프 기술을 활용해 연구하고 있습니다. 또한 당뇨병 및 비만과 관련된 장내 호르몬(GLP-1)의 신경조절 기전과 유전적 요인에 의한 스플라이싱 이상이 뇌질환에 미치는 영향에 대해서도 탐구하고 있습니다.

식이 행동뇌 신경회로GLP-1 수용체스플라이싱 조절비만 신경생물학

연구 현황

논문 수
141
총 인용 수
1,381
최근 5년 논문
19
주요 분야
보건학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
19총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
224총합
20222023202420252026

주요 논문

15
1
논문|인용수 33·2023
Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice
Young Hee Lee, Yu‐Been Kim, Kyu Sik Kim, Mirae Jang, Ha Young Song, Sang-Ho Jung, Dong-Soo Ha, Joon Seok Park, Jaegeon Lee, Kyung Min Kim, Deok-Hyeon Cheon, Inhyeok Baek
SJR Q1Nature CommunicationsOA

Abstract For survival, it is crucial for eating behaviours to be sequenced through two distinct seeking and consummatory phases. Heterogeneous lateral hypothalamus (LH) neurons are known to regulate motivated behaviours, yet which subpopulation drives food seeking and consummatory behaviours have not been fully addressed. Here, in male mice, fibre photometry recordings demonstrated that LH leptin receptor (LepR) neurons are correlated explicitly in both voluntary seeking and consummatory behavio

Endocrine and Autonomic SystemsNeuroscience
2
논문|인용수 32·2002
Estimation of Ammonia Emission in South Korea
Young Hee Lee, Soon-Ung Park
SJR Q2Water Air & Soil Pollution
Ecology, Evolution, Behavior and SystematicsAgricultural and Biological Sciences
3
리뷰|인용수 17·2019
Food Craving, Seeking, and Consumption Behaviors: Conceptual Phases and Assessment Methods Used in Animal and Human Studies
Young Hee Lee, Meelim Kim, Mi-Woo Lee, Dongju Shin, Dong-Soo Ha, Joon Seok Park, Yu‐Been Kim, Hyung Jin Choi
SJR Q1Journal of Obesity & Metabolic SyndromeOA

technologies in the neuroscience field allows us to reevaluate the multiple components and phases of food-related behaviors. Focused on the cognitive, executive, behavioral and temporal aspects, food-related behaviors can be distinguished into appetitive phase (food craving→food seeking) and consummatory phase (food consumption). Food craving phase is an internal state or stage in which the animal has the motivation to eat the food but there is no actual food specific behaviors or actions. Food

Nutrition and DieteticsNursing
4
논문|인용수 14·2009
In-Depth Assessment of the Nutritional Status of Korean American Elderly
Young Hee Lee, Jong‐Eun Lee, Miyong T. Kim, Hae‐Ra Han
SJR Q1Geriatric Nursing
Nutrition and DieteticsNursing
5
논문|인용수 14·2010
Development of a Patient-Doctor Communication Skills Model for Medical Students
Young Hee Lee, Young‐Mee Lee
SJR Q2Korean journal of medical educationOA

PURPOSE: Communication is a core clinical skill that can be taught and learned. The authors intended to develop a patient-doctor communication model for teaching and assessing undergraduate medical students in Korea. METHODS: To develop a model, literature reviews and an iterative process of discussion between faculty members of a communication skills course for second year medical students were conducted. The authors extracted common communication skill competencies by comparing the Kalamazoo C

General Health ProfessionsHealth Professions
6
editorial|인용수 13·2017
GLP-1 Based Combination Therapy for Obesity and Diabetes
Young Hee Lee, Hee Won Lee, Hyung Jin Choi
SJR Q1Journal of Obesity & Metabolic SyndromeOA

Obesity and its comorbidities, such as type 2 diabetes, are major public health diseases in modern society. Despite the currently significant unmet needs of type 2 diabetes patients, effective and safe pharmacological treatments that deliver adequate weight loss and glucose control have not been discovered. Anorectic gut hormone, glucagon-like peptide 1 (GLP-1), is widely used to treat obesity and diabetes.1,2 GLP-1 is a type of incretin released from the L cells of the large intestine and di

Endocrinology, Diabetes and MetabolismMedicine
7
논문|인용수 9·2008
The Relationship Between Personality Types, Communication Skills and Learning Attitudes in Premedical Students
Young Hee Lee, Young‐Mee Lee, Byung‐Soo Kim
SJR Q2Korean journal of medical educationOA

The purpose of this study was to explore the relationship between the personality types of premedical students and their self-assessed communication skills and attitudes toward a communication skills course.

Social PsychologyPsychology
8
논문|인용수 8·2018
Genetic variation affecting exon skipping contributes to brain structural atrophy in Alzheimer's disease.
Young Hee Lee, Seonggyun Han, Dong‐Wook Kim, Dokyoon Kim, Emrin Horgousluoglu, Shannon L. Risacher, Andrew J. Saykin, Kwangsik Nho
PubMedOA

Genetic variation in cis-regulatory elements related to splicing machinery and splicing regulatory elements (SREs) results in exon skipping and undesired protein products. We developed a splicing decision model to identify actionable loci among common SNPs for gene regulation. The splicing decision model identified SNPs affecting exon skipping by analyzing sequence-driven alternative splicing (AS) models and by scanning the genome for the regions with putative SRE motifs. We used non-Hispanic Ca

Cellular and Molecular NeuroscienceNeuroscience
9
논문|인용수 8·2010
Content Analysis of Standardized-Patients' Descriptive Feedback on Student Performance on the CPX
Young Hee Lee, Young‐Mee Lee, Byung Soo Kim
SJR Q2Korean journal of medical educationOA

PURPOSE: The goal of this study was to explore what kind of additional information is provided by the descriptive comments other than the rating scales, on the physician-patient interaction (PPI) in the clinical performance examination (CPX) and its feedback role in identifying students' strengths and weaknesses in communication skills. METHODS: The data were collected from 18 medical schools in Seoul and Gyeonggi region, which participated in the CPX for fourth-year medical students in 2006 and

Public Health, Environmental and Occupational HealthMedicine
10
논문|인용수 7·2005
A Study of Biodegradable Superabsorbent Materials Based on Acrylonitrile Grafted Sodium Alginate
Young Hee Lee, Jung Soo Kim, Han Do Kim
SJR Q4Key engineering materialsOA

Biodegradable superabsorbents, hydrolyzed AN(acrylonitrile)-grafted-SA(sodium alginate) copolymers were prepared in this study by graft copolymerization of acrylonitrile on sodium alginate and the subsequent hydrolysis of the resulting grafted copolymer. The absorbency was found to significantly depend on the % add-on, graft copolymerization conditions and hydrolysis conditions. The optimum condition for graft copolymerization to obtain the maximum % add-on (64.5%) was 4g SA, 12g AN, and 8.42g H

Molecular MedicineBiochemistry, Genetics and Molecular Biology
11
논문|인용수 7·2024
A normative framework dissociates need and motivation in hypothalamic neurons
Kyu Sik Kim, Kyu Sik Kim, Young Hee Lee, Jong Won Yun, Yu‐Been Kim, Ha Young Song, Joon Seok Park, Sang-Ho Jung, Jong‐Woo Sohn, Ki Woo Kim, Ki Woo Kim, HyungGoo R. Kim
SJR Q1Science AdvancesOA

Physiological needs evoke motivational drives that produce natural behaviors for survival. In previous studies, the temporally intertwined dynamics of need and motivation have made it challenging to differentiate these two components. On the basis of classic homeostatic theories, we established a normative framework to derive computational models for need-encoding and motivation-encoding neurons. By combining the model-based predictions and naturalistic experimental paradigms, we demonstrated th

Endocrine and Autonomic SystemsNeuroscience
12
논문|인용수 6·2017
A Study on Ethical Consumption Behavior According to College Students’ Personality Traits and Perception of Consumption Society
Young Hee Lee
Family and environment researchOA

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Information Systems and ManagementDecision Sciences
13
논문|인용수 5·2011
Fear of Falling, Depression, Physical Fitness and Physical Activity among Community Dwelling Elders
Young Hee Lee, Mi-Kyoung Choi
SJR Q3Korean Journal of Adult Nursing

Purpose: This study was designed to examine fear of falling, depression, physical fitness, and physical activity and further to identify the factors that predict physical activity among community dwelling elders. Methods: This study was a cross-sectional descriptive survey. Participants were 153 community dwelling elders from G city. Data were collected using structured questionnaires and were analyzed using descriptive statistics, x 2 -test, t-test, ANOVA, and multinominal logistic regression a

General Health ProfessionsHealth Professions
14
논문|인용수 3·2022
Exploration of the Perceptions of Difficulties Experienced by High School Teachers in the Process of Operating the High School Credit System and the Role Contents
Young Hee Lee, Jihyun Yoon, Jeonghyun Yun
Korean Association For Learner-Centered Curriculum And Instruction

Objectives For the successful introduction and settlement of the high school credit system, it is important to expand the role of teachers related to the operation of the high school credit system and secure expertise. To this end, it is necessary to examine the actual difficulties experienced by high school teachers in the process of operating the high school credit system and derive the new role performance required by teachers based on this. Methods Therefore, in this study, the difficulties

PharmacologyPharmacology, Toxicology and Pharmaceutics
15
논문|인용수 2·2011
Gender Differences in Depression According to the Study of the Elderly
Young Hee Lee
Journal of Wellness
General Health ProfessionsHealth Professions

대표 연구 분야

General Health ProfessionsComputer Networks and CommunicationsNutrition and DieteticsEndocrine and Autonomic SystemsCell BiologyMolecular Biology

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