박윤길 교수

Although cultured myoblast transplantation has been extensively studied as a gene complementation approach to muscular dystrophy treatment, clinical success has still been limited. The inability to adequately isolate and purify myoblasts presents a major limitation to the production of sufficient myoblasts for engrafting purposes. This study attempted to purify myoblasts from primary culture by magnetic-activated cell sorting (MACS), complement-mediated cytotoxicity, and a preplating technique.

Purpose: Myotonic dystrophy type 1 (DM1) is characterized by progressive muscular weakness with symptoms caused by involvementof the brain. The aim of this study was to delineate global changes in cortical thickness and white matter integrity in patients with DM1, compared to age-matched healthy controls, and in brain areas highly correlated with CTG repeat size. Materials and Methods: Cortical thickness and white matter integrity were compared in nine adult DM1 patients and age matched healthy

Bronchiolitis obliterans (BO) is a late onset complication of allogeneic hematopoietic stem cell transplantation (HSCT), and treatment outcome is dismal if it does not respond to immunosuppressive therapy. A 21-year-old male diagnosed with acute myeloid leukemia received an allogeneic HSCT from human leukocyte antigen-identical sibling donor. Twenty one months after transplantation, he developed progressive dyspnea and was diagnosed BO. Despite standard immunosuppressive therapy, the patient rap

Purpose: For patients with neuromuscular disease, air stacking, which inflates the lungs to deep volumes, is important for many reasons. However, neuromuscular patients with severe glottic dysfunction or indwelling tracheostomy tubes cannot air stack effectively. For these patients, we developed a device that permits deep lung insufflations substituting for glottic function. Materials and Methods: Thirty-seven patients with bulbar-innervated muscle weakness and/or tracheostomies were recruited.

Dysphagia is a frequent symptom in Parkinson’s disease (PD) and the main cause of aspiration pneumonia and death of patients with PD. It is also associated with nutritional problems, pulmonary complications and quality of life of PD patients. The prevalence is very high in PD patients, varying from 77% to 95%, but exact pathophysiology and mechanism remains obscure. Dysphagia associated with PD has been reported to affect all stages of swallowing including oral, pharyngeal, esophageal phase, but

Bell's palsy is a commonly observed cranial nerve VII dysfunction that can result in compromised facial appearance and function. It represents about 50% to 60% of all etiologies of peripheral acute idiopathic facial paresis with a variable annual incidence in different regions ranging from 8 to 52.8 per 100,000

Objective To report successful cases of extubation from invasive mechanical ventilation at our institution using pulmonary rehabilitation consisting of noninvasive ventilation (NIV) in neuromuscular patients with experience of reintubation.Methods Patients who experienced extubation failure via the conventional weaning strategy but afterwards had extubation success via NIV were studied retrospectively. Continuous end-tidal CO2 (ETCO2) and pulse oxyhemoglobin saturation (SpO2) monitoring were per

Objective To identify which combination of motor evoked potentials (MEPs) and somatosensory evoked potentials (SEPs) is most reliable for postoperative motor deterioration during spinal cord tumor surgery, according to anatomical and pathologic type.Methods MEPs and SEPs were monitored in patients who underwent spinal cord tumor surgery between November 2012 and August 2016. Muscle strength was examined in all patients before surgery, within 48 hours postoperatively and 4 weeks later. We analyze

Motor evoked potentials (MEPs) with somatosensory evoked potentials (SSEPs) have been used to prevent neurological\ncomplication during cerebral aneurysm surgery. This case shows postoperative anterior choroidal artery (AChA)\ninfarction with decreased SSEPs, in spite of preserved MEPs during aneurysm clipping. A 58-year-old man with\nruptured aneurysm between right internal carotid artery and AChA received aneurysm clipping. During temporal arterial\nclipping, left tibial SSEPs amplitude decrea