최윤희 교수

부모와 유아 사이에 이루어지는 상호작용은 유아의 발달에 많은 영향을 미친다. 본 연구는 어머니와 발달지체 유아와의 상호작용을 증가시키기 위하여 어머니의 민감성(sensitivity), 반응성(responsiveness), 상호성(reciprocity) 증진을 목표로 한 반응적 의사소통 전략을 훈련하였다. 어머니훈련의 효과를 확인하기 위하여 대상자간 중다간헐 기초선 설계를 사용하였으며, 가정에서 일상적으로 이루어지는 놀이 상황에서 발생하는 상호작용을 관찰하였다. 연구 결과, 어머니훈련을 통해 어머니와 발달지체 유아의 상호작용 발생률이 증가하였고 중재 종료 4주 후에도 유지되었다. 이러한 결과를 토대로 상호성을 강조한 부모-자녀 간 의사소통과 발달지체 유아의 조기 중재 시 부모 지원을 위한 상호작용 프로그램의 필요성을 논의하였다.

Gastric cancer is one of the most common causes of cancer-related mortality worldwide. Expression of the tumor suppressor, promyelocytic leukemia (PML) protein, is reduced or abolished in gastric carcinomas, in association with an increased level of lymphatic invasion, development of higher pTNM staging, and unfavorable prognosis. Herein, we investigated the relationship between the extent of tumor-infiltrating lymphocytes and the status of PML protein expression in advanced gastric carcinoma. W

Neuroinflammation, a significant contributor to various neurodegenerative diseases, is strongly associated with the aging process; however, to date, no efficacious treatments for neuroinflammation have been developed. In aged mouse brains, the number of infiltrating immune cells increases, and the key transcription factor associated with increased chemokine levels is nuclear factor kappa B (NF-κB). Exosomes are potent therapeutics or drug delivery vehicles for various materials, including protei

OBJECTIVES: Facial bone fractures secondary to head trauma are more common in children than in adults. Recently, multidetector row computed tomography (CT) has been considered superior to conventional radiography. Some studies have reported that facial soft tissue injuries require both facial and brain CT and that brain CT is helpful in screening facial bone fractures. However, these studies included only adult patients. The aim of this study was to evaluate the diagnostic performance of brain C

BACKGROUND/OBJECTIVE: (AK) has widely been utilized for the purpose of general health improvement among Asian, its functionality and mechanism of action. The aim of this study was to determine the protective effect of ethanol extract of AK (AK-Ex) on acute hepatotoxicity induced by acetaminophen (AAP) in HepG2 human hepatocellular liver carcinoma cells and HepaRG human hepatic progenitor cells. MATERIALS/METHODS: AK-Ex was prepared HepG2 and HepaRG cells were cultured with various concentrations

Aging is a major risk factor for common neurodegenerative diseases. Although multiple molecular, cellular, structural, and functional changes occur in the brain during aging, the involvement of caveolin-2 (Cav-2) in brain ageing remains unknown. We investigated Cav-2 expression in brains of aged mice and its effects on endothelial cells. The human umbilical vein endothelial cells (HUVECs) showed decreased THP-1 adhesion and infiltration when treated with Cav-2 siRNA compared to control siRNA. In

본 연구는 일반유아를 대상으로 한 반편견교육의 동향을 살펴봄으로서 장애 유아와 일반유아의 사회적 통합을 위한 반편견교육의 방향을 제시하고자 하였다. 이를 위해 장애 유아에 대한 일반 유아의 인식과 태도에 관한 연구와 장애를 주제로 한 반편견교육에 관한 국내외 연구 35편을 분석하였다. 분석 결과는 1) 연구 방법과 2) 교육 환경으로 구분하여 반편견교육의 내용과 방법을 제시하였다. 반편견교육은 비통합 환경에서의 간접 경험으로 제공되는 경우가 많았고, 본래 목적에 비해 지나치게 협소하고 부분적인 내용으로 진행되고 있음을 알 수 있었다. 이러한 분석 결과를 토대로 현장 적용을 위한 시사점을 논의하였으며 향후 필요한 후속 연구를 제언하였다.

Complex regional pain syndrome (CRPS) is a condition associated with neuropathic pain that causes significant impairment of daily activities and functioning. Nuclear factor kappa B (NFκB) is thought to play an important role in the mechanism of CRPS. Recently, exosomes loaded with super-repressor inhibitory kappa B (Exo-srIκB, IκB; inhibitor of NFκB) have been shown to have potential anti-inflammatory effects in various inflammatory disease models. We investigated the therapeutic effect of Exo-s

BACKGROUND: Serum neutrophil gelatinase-associated lipocalin (NGAL) could be used as a predictive marker of acute kidney injury (AKI) in patients with return of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest (OHCA) who are managed with targeted temperature management (TTM). However, the NGAL measurement timepoints vary from immediately after ROSC to several days later. The primary objective of this study was to determine an association between AKI and NGAL, both immediately