진윤희 교수

Control of neural stem cell (NSC) self-renewal and differentiationis of great importance to improve itstherapeutic efficacy in the treatment of neurodegenerative diseases. Neurosphere culture for NSCexpansion under undifferentiation condition determines the self-renewal capacity and differentiationpropensity of NSCs. In this study, we examined the effects of controlled crosstalk between endothelialcells (ECs) and NSC neurospheres on self-renewal, differentiation, and functions of NSCs. Cultures

Purpose: Conventional 2-dimensional cultures and animal models have limited ability to reproduce the structural complexity, dynamic mechanical cues, and sustained functionality of native skeletal muscle tissue. To overcome these limitations, skeletal muscle-on-a-chip platforms have been developed as advanced in vitro systems for studying muscle physiology, pathology, and regeneration. Current Concepts: These microengineered systems incorporate essential features of skeletal muscle, including 3-d