박윤정 교수

[6]-Gingerol, a major phenolic compound derived from ginger, has anti-bacterial, anti-inflammatory and anti-tumor activities. While several molecular mechanisms have been described to underlie its effects on cells in vitro and in vivo, the underlying mechanisms by which [6]-gingerol exerts anti-tumorigenic effects are largely unknown. The purpose of this study was to investigate the action of [6]-gingerol on two human pancreatic cancer cell lines, HPAC expressing wild- type (wt) p53 and BxPC-3 e

The estimation of antenatal amniotic fluid (AF) volume (AFV) is important as it offers crucial information about fetal development, fetal well-being, and perinatal prognosis. However, AFV measurement is cumbersome and patient specific. Moreover, it is heavily sonographer-dependent, with measurement accuracy varying greatly depending on the sonographer's experience. Therefore, the development of accurate, robust, and adoptable methods to evaluate AFV is highly desirable. In this regard, automatio

The incidence of CVD after delivery was higher in women who had preeclampsia during pregnancy.

Kale (<i>Brassica oleracea</i> L. <i>Acephala</i> Group) is the rich source of medicinal value sulphur compounds, glucosinolates (GLSs). The aim of this study was to investigate the effect of different proportion of sulphur (S) supplementation levels on the accumulation of GLSs in the leaves of the kale cultivar ('TBC'). High performance liquid chromatography (HPLC) separation method guided to identify and quantify six GSLs including three aliphatic (progoitrin, sinigrin and gluconapin) and thre

Neuroblastoma is the most common pediatric extracranial solid tumor derived from primitive neural crest cells of the sympathetic nervous system. Although one-fifths of all neuroblastomas occurs within the thorax, thoracic neuroblastomas detected in fetus have been rarely reported. We report a case of fetal thoracic neuroblastoma with massive pleural effusion detected with prenatal ultrasonography. A 34-year-old Korean second-gravida was referred to our hospital at 30 weeks of gestation for evalu

Introduction Alzheimer’s disease (AD) has significant public health concerns in the aging society. AD can compromise brain function and lead to severe neurological abnormalities associated with dementia. The human Apolipoprotein E (ApoE4) gene is a strong risk factor for AD. However, comprehensive analyses and improvements of mouse models expressing ApoE4 remain largely unexplored. Methods ApoE4 knock-in (KI) mice were used to investigate the role of humanized ApoE4 in hippocampal histological c

생분해성 고분자인 poly(lactic acid)(PLA)에 항균성 물질들의 첨가가 열적 특성에 미치는 영향은 체계적으로 보고된 바가 드물다. 본 연구에서는 항균성 물질인 quercetin을 PLA에 첨가하였을 때 그 열적 특성의 변화를 분석하였다. Quercetin 입자의 존재에 의해 PLA의 결정화 속도가 증가하여, 냉결정화 온도가 낮아지고, k값의 상승과 half-crystallization 시간이 감소하였다. 녹는점이나 용융엔탈피의 경우 증발결정화에서는 유의미한 변화를 보이지 않았고, 용융결정화의 경우 낮아진 용융엔탈피 값을 확인할 수 있었다. Quercetin/PLA 항균 필름의 열적 특성에 대한 이해는 PLA의 생분해성 항균재료 활용성을 고취시킬 수 있을 것으로 예상된다.

Vaginal stenosis, or gynetresia, commonly results from a congenital defect, while acquired gynetresia is a rare condition. Reported contributors to acquired gynetresia include chronic graft-versus-host reaction, radiotherapy for gynecologic malignancies, female genital mutilation, postpartum foreign body insertion, or chemical insertion. We report a case of postpartum gynetresia, that was attributed to neither a foreign body nor chemicals. A 33-year-old Korean primigravid woman was referred to o

Purpose of investigation: To investigate the expression of sirtuin1 and hypoxia-inducible factor-1&#x03B1; in normal and preeclamptic placenta under hypoxia. Materials and Methods: Twelve women with severe preeclampsia and ten normotensive women were enrolled in the study. Villous explants from the placenta were collected following cesarean delivery. Quantitative reverse transcription polymerase chain reaction, Western blot analysis, and immunohistochemical staining were performed to evaluate mR

A case of thoracic neuroblastoma with massive pleural effusion detected by prenatal ultrasonography is presented. A 34-year-old Korean primigravida was referred to our hospital at 30 weeks of gestation for evaluation of right lung mass. A 3.8x3.3 cm2 sized well-defined hyperechoic mass in right thorax with right pleural effusion was initially suspected as teratoma. However, the mass was considered as malignant condition at 33 weeks of gestation on follow-up ultrasonography due to growing solid m