[论文解读] Recommended Implementation of Quantitative Susceptibility Mapping for Clinical Research in The Brain: A Consensus of the ISMRM Electro-Magnetic Tissue Properties Study Group

Berkin Bilgic̦, Mauro Costagli+16 more|arXiv (Cornell University)|Jul 5, 2023

Advanced MRI Techniques and Applications被引用 15

一句话总结

该论文提供基于共识的建议，用于在脑部临床研究中实现定量磁化率映射（QSM），覆盖采集、处理、分析和报告，促进标准化。

ABSTRACT

This article provides recommendations for implementing quantitative susceptibility mapping (QSM) for clinical brain research. It is a consensus of the ISMRM Electro-Magnetic Tissue Properties Study Group. While QSM technical development continues to advance rapidly, the current QSM methods have been demonstrated to be repeatable and reproducible for generating quantitative tissue magnetic susceptibility maps in the brain. However, the many QSM approaches available give rise to the need in the neuroimaging community for guidelines on implementation. This article describes relevant considerations and provides specific implementation recommendations for all steps in QSM data acquisition, processing, analysis, and presentation in scientific publications. We recommend that data be acquired using a monopolar 3D multi-echo GRE sequence, that phase images be saved and exported in DICOM format and unwrapped using an exact unwrapping approach. Multi-echo images should be combined before background removal, and a brain mask created using a brain extraction tool with the incorporation of phase-quality-based masking. Background fields should be removed within the brain mask using a technique based on SHARP or PDF, and the optimization approach to dipole inversion should be employed with a sparsity-based regularization. Susceptibility values should be measured relative to a specified reference, including the common reference region of whole brain as a region of interest in the analysis, and QSM results should be reported with - as a minimum - the acquisition and processing specifications listed in the last section of the article. These recommendations should facilitate clinical QSM research and lead to increased harmonization in data acquisition, analysis, and reporting.

研究动机与目标

• 在快速方法学进展中推动脑部研究中QSM方法的标准化。
• 为QSM的数据采集、处理和分析提供实用、逐步的指南。
• 确保在科学出版物中一致报告QSM结果，以实现跨研究的可比性。

提出的方法

• 推荐单极3D多回波GRE采集。
• 建议以DICOM保存相位图并应用精确的相位展开。
• 建议在背景移除前将多回波图像结合，并在创建脑掩模时考虑相位质量。
• 主张在脑掩模内使用SHARP或基于PDF的方法进行背景场移除。
• 建议使用带稀疏性正则化的偶极反演。
• 建议报告相对指定参考的磁化率值，包括以全脑作为参考ROI。

实验结果

研究问题

• RQ1 在跨研究的QSM脑测量中，哪些采集与处理选择能将变异性降至最低？
• RQ2 QSM结果应如何进行参考和报告，以实现跨研究的可比性？
• RQ3 哪些背景移除和偶极反演策略能产生可重复、可再现的脑部磁化率图？
• RQ4 在QSM结果的出版物中应包含哪些最低报道标准？

主要发现

• 在适当的方法下，QSM技术可产生可重复和可再现的脑部磁化率图。
• 标准化的流程可以在研究之间统一数据采集、处理和报告。
• 这些建议覆盖从数据采集到在科学出版物中的呈现的所有步骤，以促进临床QSM研究。