东京大学、京都大学、大阪大学等日本QS前10名大学的研究室信息。
Professor Eiji Oki's research lab specializes in advanced networking architectures and algorithms, with a focus on scalable switch design, efficient traffic engineering in multi-layer networks, and dynamic routing in IP-optical integrated environments. The lab explores innovative scheduling and path computation techniques—such as round-robin-based dispatching and PCE-enabled inter-layer optimization—to enhance throughput and resource utilization in high-speed communication networks. Their work bridges theoretical modeling and practical implementation, particularly in generalized MPLS (GMPLS) and photonic networking systems. The lab also investigates mathematical programming approaches for network control and optimization, aiming to improve performance and reliability in next-generation networks.
Professor Akihisa Fukuda's research lab focuses on the molecular and epigenetic mechanisms underlying pancreatic development and tumorigenesis, with a particular emphasis on transcriptional regulators such as Ptf1a, chromatin remodeling complexes (e.g., SWI/SNF and BRG1), and tumor suppressor genes like RECK. The lab investigates how dysregulation of these factors contributes to pancreatic cancer initiation, progression, and metastasis, especially in the context of pancreatic ductal adenocarcinoma (PDAC) and precursor lesions such as PanIN and IPMN. Using genetically engineered mouse models and clinical correlation studies, the lab explores the roles of epigenetic regulators, EMT, and tumor microenvironment remodeling in cancer pathogenesis and therapeutic response. Their work also extends to rare cardiac manifestations of metastatic disease, highlighting translational insights from clinical case studies.
Professor Shotaro Takano's research lab focuses on the molecular mechanisms underlying osteoarthritis (OA) pathogenesis, with a particular emphasis on the role of immune cells—especially macrophages—in regulating inflammatory mediators and pain-related factors in synovial tissue. The lab investigates key signaling pathways involving nerve growth factor (NGF), calcitonin gene-related peptide (CGRP), vascular endothelial growth factor (VEGF), and cytokines such as TNF-α and IL-1β, exploring their contributions to OA-related pain and joint destruction. Additionally, the lab examines environmental metal isotopes as tracers for pollution sources, reflecting a multidisciplinary approach linking environmental science with biomedical research. Recent work highlights the crosstalk between immune cells and stromal cells in the synovium, revealing novel therapeutic targets for OA.
Professor Taketoshi Minato's research lab specializes in the atomic-scale understanding of functional materials, with a focus on defect engineering, interfacial phenomena, and charge-lattice interactions in oxides and battery materials. The lab combines advanced in situ characterization techniques—such as in situ neutron reflectivity, frequency modulation atomic force microscopy (FM-AFM), and scanning tunneling microscopy (STM)—with theoretical simulations to explore how atomic-level defects and interfacial structures govern physical and electrochemical properties. Current research directions include the design of next-generation batteries (e.g., fluoride shuttle batteries and lithium-ion batteries), the manipulation of surface hydrogen and oxygen vacancies in metal oxides, and the integration of nanocatalysts like gold clusters with defective titania. The lab aims to bridge fundamental surface science with practical applications in energy conversion and storage.
Professor Abhishek Lakshman Pillai's research lab specializes in computational fluid dynamics and combustion science, with a focus on spray combustion, turbulence, and combustion noise in advanced engine systems. The lab investigates fundamental mechanisms of heat transfer, flame-wall interactions, and instability phenomena in compression ignition and lean-premixed combustors using high-fidelity numerical simulations such as Large-Eddy Simulation (LES) and Direct Numerical Simulation (DNS). A key emphasis is placed on modeling multiphase reactive flows, radiative heat loss, and acoustic emissions in alternative fuel systems like hydrogen and ethanol. Additionally, the lab explores hardware-software co-design for embedded systems, particularly in optimizing VLIW processor architectures for performance, energy efficiency, and fault tolerance through runtime error detection strategies.
Professor Mikihito Hirohata's research lab specializes in structural integrity and durability of steel structures, with a focus on corrosion behavior, residual stress control, and fatigue performance enhancement in steel bridges and civil engineering infrastructures. The lab conducts experimental and numerical studies on accelerated corrosion testing, induction heating for residual stress reduction, and advanced joining techniques such as bonding-assisted welding. Their work aims to improve the safety, service life, and maintenance efficiency of existing steel structures through innovative field-applicable thermal treatments and corrosion monitoring methods.
Professor Keisuke Uemura's research lab specializes in musculoskeletal biomechanics and medical imaging, focusing on the three-dimensional (3D) assessment of hip joint pathoanatomy using advanced imaging techniques such as CT and DXA. The lab investigates dynamic and static femoral head coverage, pelvic sagittal inclination, and implant positioning in conditions like hip dysplasia and osteoarthritis, aiming to improve diagnostic accuracy and surgical planning. A key focus is the development of open-source, clinically applicable tools for quantitative imaging analysis, particularly in total hip arthroplasty and osteoporosis screening. The lab integrates patient-specific 3D modeling with in-vivo kinematic data to bridge the gap between anatomical structure and functional joint behavior.
Professor Rongyang Xu's research lab specializes in nanophotonics and photonic materials, focusing on the design and application of all-dielectric metasurfaces and Mie resonators for advanced optical devices. The lab explores fundamental principles such as degenerate critical coupling and Mie resonances to achieve perfect absorption, high sensitivity, and low optical loss in the visible and near-infrared spectrum. Key research directions include broadband and wavelength-selective absorbers, graphene-based photodetectors, and CMOS-compatible photonic integrated circuits for energy-efficient neuromorphic computing. The lab's work bridges nanophotonics with practical applications in sensing, imaging, and optoelectronics.
Professor Hyota Takamatsu's research lab focuses on innate immune signaling, particularly the molecular mechanisms underlying inflammasome activation and its role in sterile and infectious inflammatory diseases. The lab investigates how subcellular organelles, especially lysosomes, regulate immune responses through scaffolding complexes such as Ragulator, with a strong emphasis on NLRP3 inflammasome dynamics. They also explore biomarker discovery in autoimmune diseases, particularly lupus nephritis, by assessing bioactive forms of molecules like BAFF and type I interferons. Their work bridges basic immunology with translational applications in inflammatory and autoimmune disorders.
Professor Ratmalgre Koala's research lab specializes in advancing integrated terahertz photonics, focusing on all-silicon dielectric waveguides, low-loss waveguide components, and photonic integrated circuits for high-data-rate wireless communications and short-reach interconnects. The lab pioneers ultra-broadband, compact, and low-loss THz devices such as Y-junctions, gradient-index antennas, and photonic crystal waveguides, enabling applications in 6G wireless systems and high-speed data links. By leveraging monolithic integration and advanced silicon processing techniques, the lab drives innovation in compact, efficient, and scalable THz systems for next-generation communication and sensing technologies.
Professor Wataru Ise's research lab focuses on the cellular and molecular mechanisms underlying T follicular helper (Tfh) cell differentiation, germinal center reactions, and the generation of long-lived plasma cells that sustain long-term humoral immunity. The lab investigates how antigen-specific B cells and dendritic cells instruct Tfh cell responses during primary and recall immune responses, with a particular emphasis on the role of Bcl6 and pMHC-II complexes in memory Tfh cell reactivation. Additionally, the lab explores the regulation of plasma cell homeostasis and niche-dependent survival in the bone marrow, as well as the mechanisms of peripheral T cell tolerance, especially in the context of oral tolerance. These studies aim to clarify the balance between effective immunity and immune regulation, with implications for vaccine design and autoimmune disease prevention.
Professor Kenji Osabe's research lab focuses on epigenetic regulation in plants, particularly the roles of DNA methylation, histone modifications, and non-coding RNAs in gene expression, genome stability, and stress responses. The lab investigates epigenetic mechanisms underlying phenotypic diversity, especially in crop species like cotton and Brassica rapa, with an emphasis on how epigenetic modifications contribute to development and adaptation. Key research directions include the epigenetic regulation of transgenes and repetitive elements, the interplay between lncRNAs and small RNAs, and the molecular basis of epigenetic inheritance in allopolyploid plants.
Professor Naoyuki Yamamoto's research lab specializes in the discovery and characterization of bioactive peptides derived from food proteins, particularly milk caseins, through enzymatic hydrolysis. The lab focuses on identifying peptides with antihypertensive effects, especially those inhibiting angiotensin I-converting enzyme (ACE), and evaluating their physiological impacts in animal models and clinical trials. A key research direction involves translating these findings into functional foods and clinically validated health products, aligning with Japan’s FOSHU (Foods for Specified Health Use) system. The lab also explores the broader potential of bioactive peptides in promoting cardiovascular and gastrointestinal health.
Professor Chun-Yi Chen's research lab specializes in the design and application of advanced nanostructured materials for sustainable energy conversion and environmental remediation. The lab focuses on developing innovative yolk@shell and hollow nanostructures—particularly those incorporating plasmonic and semiconducting components—for efficient solar-driven water splitting, with an emphasis on photocatalytic, electrocatalytic, and photoelectrochemical processes. A key research direction involves structural engineering of nanomaterials to optimize light absorption, charge separation, and surface reactivity. The lab also investigates the propagation of optical pulses in atmospheric turbulence, contributing to the advancement of free-space optical communication systems.
Professor Nobuhiko Iki's research lab specializes in supramolecular chemistry, focusing on the design and synthesis of macrocyclic receptors such as calixarenes and thiacalixarenes for selective metal ion recognition and binding. The lab investigates the structural and electronic factors governing host-guest interactions, particularly the role of sulfur and oxygen donor atoms in enhancing affinity and selectivity toward transition and lanthanide ions. Key research directions include solvent extraction behavior, luminescent sensing using lanthanide complexes, and the development of water-soluble receptors for environmental and analytical applications.
Professor Yuichi Kozawa's research lab specializes in advanced optical manipulation and nanoscale light focusing using engineered polarization states and vector beams. The lab focuses on radially and azimuthally polarized laser beams, superoscillation phenomena, and high-numerical-aperture focusing to achieve sub-diffraction-limited resolution. Key research directions include optical trapping of microparticles, high-resolution confocal microscopy, and the design of novel optical elements for beam shaping. The lab combines theoretical modeling, numerical simulations, and experimental validation to push the limits of optical imaging and manipulation at the nanoscale.
Professor Yoshiaki Kanamori's research lab specializes in nanophotonics and nanostructured surfaces, focusing on the design, fabrication, and characterization of subwavelength structures for advanced optical applications. Key research directions include antireflection coatings using two-dimensional subwavelength gratings, wavelength-selective filters, and enhanced light extraction in optoelectronic devices such as LEDs. The lab employs advanced nanofabrication techniques like electron beam lithography and fast atom beam etching to realize high-aspect-ratio nanostructures on various substrates, including silicon, glass, and III-V semiconductors. Theoretical modeling using rigorous coupled-wave analysis is closely integrated with experimental validation to optimize optical performance across visible to near-infrared wavelengths.
Professor Shin-ichiro M. Nomura's research lab specializes in the design and engineering of artificial cells and biomimetic systems, focusing on synthetic biology, membrane dynamics, and molecular transport. Key research directions include the encapsulation and functional expression of proteins in cell-sized lipid vesicles, the development of DNA origami-based nanopores for controlled molecular communication, and the integration of artificial components into living cells via electrofusion techniques. The lab also explores prebiotic relevance of lipid-nucleic acid interactions and applies theoretical modeling to industrial processes such as coal injection in blast furnaces, demonstrating a unique interdisciplinary approach bridging biology, materials science, and chemical engineering.
Professor Shuhei Yabe's research lab specializes in the discovery and characterization of novel microbial taxa, particularly from extreme and understudied environments such as geothermal soils, compost, and polar ecosystems. The lab focuses on uncultured or poorly understood bacterial lineages—especially within the phylum *Chloroflexi* and the recently recognized *Ktedonobacteria*—to explore their ecological roles, physiological traits, and biotechnological potential, including the production of novel natural products and bioactive compounds. A key research direction involves developing molecular tools, such as 16S rRNA gene-targeted primers, to study microbial diversity and community structure in complex environments. The lab also emphasizes polyphasic taxonomy, combining genomics, physiology, and chemotaxonomy to describe new species with unique metabolic capabilities, such as thermophilic, spore-forming actinomycete-like bacteria and aerobic anoxygenic phototrophs.
Professor Takashi Sakamaki's research lab specializes in aquatic ecosystem ecology, focusing on the biogeochemical dynamics of organic matter across stream-forest and estuarine-terrestrial interfaces. The lab investigates how landscape characteristics, such as land use and riparian forest conditions, influence the quality and quantity of particulate organic matter (POM) and its role in shaping food web dynamics and sediment carbon cycling. Key research directions include stream–landscape linkages, oyster biodeposition processes, and the long-term stability of carbon in tidal flats, with an emphasis on understanding scale-dependent ecological processes in temperate watersheds and estuaries. The lab employs field monitoring, mesocosm experiments, and stable isotope analysis to trace organic matter flow and ecosystem function across environmental gradients.
